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Semaglutide, like most peptides , is sensitive to agitation

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The result is a porous, dry solid - often referred to as a puck or cake. Why Lyophilisation Is Used for Peptides Peptides are sensitive to: Hydrolysis (water-driven breakdown) Oxidation Microbial growth Temperature instability Removing water dramatically slows degradation

Journal of Alternative and Complementary Medicine (New York, N.Y.), 21 (1), 2230